Current Options and Future Perspectives on Bone Graft and Biomaterials Substitutes for Bone Repair, from Clinical Needs to Advanced Biomaterials Research

Biomaterials for bone regeneration.

OBJECTIVE This article reviews the literature on biomaterials used for bone regeneration. MATERIAL AND METHOD A total of seventeen bibliographic sources were found using the MEDLINE database and to avoid the variability of the search terms the thesaurus Mesh was used. RESULTS These materials act essentially due to their osteoconductive ability, although their osteoinductive capacity is bein...

Biomaterials for the Reconstructive Treatment of Periodontal Intrabony Defects. Part I. Bone Grafts and Bone Substitutes

Regeneration is defined as a reproduction or reconstruction of a lost or injured part in a way that both form and function of lost tissues are completely restored (Wikesjö and Selvig, 1999; Caton and Greenstein, 1993; Machtei, 1997; World Workshop in Periodontology, 1996). Regenerative periodontal therapy aims to predictably restore the tooth’s supporting apparatus which has been lost following...

New biomaterials for bone regeneration.

Bone-grafting techniques either with autografts or allografts still represent a challenge for reconstructive surgery.Allografts and autografts are the current strategies for filling bone defects and subsequent repair but each have drawbacks. Synthetic bone-graft substitutes, developed in an effort to overcome the inherent limitations of autograft and allograft, represent an alternative strategy...

Bone-grafting and bone-graft substitutes.

Bone grafts are often necessary to provide support, fill voids, and enhance biologic repair of skeletal defects. Autogenous bone recovered from the patient’s own iliac crest is generally considered the gold standard of bone grafts. There is a need for alternatives, however, because of limited autograft quantities, donor site morbidity, and other problems including limited biologic performance. ...

Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials